Anesthesia
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June 10, 2024
Jessica Cassavaugh, MD, PhD, receives two-year grant from the Foundation for Anesthesia Education and Research (FAER)
Jessica Cassavaugh, MD, PhD, has received a two-year grant ($80,000/year) from the Foundation for Anesthesia Education and Research (FAER) for her study “Estrogen, Inflammation and Metabolic Health; Estrogen Dependent Signaling is Protective in Metabolic Disease.” This study will investigate the impact of estrogen on the progression of metabolic disorders, particular metabolic dysfunction-associated steatotic liver disease (MASLD). MASLD is linked to increased mortality, particularly among intensive care patients, and is becoming the primary reason for liver transplantation. Aging women face a higher risk of MASLD-associated cardiovascular disease, and this study will investigate the interplay between estrogen and the aryl-hydrocarbon receptor (AhR), a recognized mediator of steatosis, as it relates to inflammation and metabolic strain. The results will provide the foundation for future research into MASLD and possible targets for interventions to prevent this condition.
