Pathology Research Highlights

Affiliated with Harvard Medical School, the Department of Pathology faculty conduct research in the further characterization of disease processes and trains the next generation of pathologists. Check back often for updates. View all publications from the last quarter.

Journals

Perspective: Sickle Cell Trait, Inequity, and the Need for Change, published in NEJM, by BIDMC pathologist Richard Haspel, MD, and hematologist Brian Carney, MD. Nov. 23, 2024.

Neutrophil extracellular traps activate hepatic stellate cells and monocytes via NLRP3 sensing in alcohol-induced acceleration of MASH fibrosis. Babuta M, Morel C, de Carvalho Ribeiro M, Calenda C, Ortega-Ribera M, Thevkar Nagesh P, Copeland C, Zhuang Y, Wang Y, Cho Y, Joshi R, Brezani V, Hawryluk D, Datta AA, Mehta J, Nasser I, Szabo G. Gut. 2024 Oct 7;73(11):1854-1869. doi: 10.1136/gutjnl-2023-331447. PMID: 38777573; PMCID: PMC11458363.

An RNA damage response network mediates the lethality of 5-FU in colorectal cancer. Chen JK, Merrick KA, Kong YW, Izrael-Tomasevic A, Eng G, Handly ED, Patterson JC, Cannell IG, Suarez-Lopez L, Hosios AM, Dinh A, Kirkpatrick DS, Yu K, Rose CM, Hernandez JM, Hwangbo H, Palmer AC, Vander Heiden MG, Yilmaz ÖH, Yaffe MB.  Cell Rep Med. 2024 Oct 15;5(10):101778. doi: 10.1016/j.xcrm.2024.101778. Epub2024 Oct 7. PMID: 39378883; PMCID: PMC11514606.

Tumor-suppressive activities for pogo transposable element derived with KRAB domain via ribosome biogenesis restriction. Tu Z, Bassal MA, Bell GW, Zhang Y, Hu Y, Quintana LM, Gokul D, Tenen DG, Karnoub AE. Mol Cell. 2024 Oct 28:S1097-2765(24)00781-0. doi: 10.1016/j.molcel.2024.09.025. Epub ahead of print. PMID: 39481384.

Preprints

New from the Winston Hide Lab: Molecular hallmarks of excitatory and inhibitory neuronal resilience and resistance to Alzheimer’s disease.